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目的：研究尼索地平β环糊精（βＣＤ）１∶１包合物的制备。方法：通过研究了βＣＤ对尼索地平的包合作用及包合后的溶解性，并比较了尼索地平βＣＤ包合物与原料药及ＰＶＰ固体分散物片的溶出度。结果：尼索地平在包合后，其水中溶解度由包合前的７．１０μｇ·ｍｌ－１提高到１５．７５μｇ·ｍｌ－１。结论：包合物的溶出度优于原料药，但不及固体分散物片。
Objective: To study the preparation of nisoldipine βcyclodextrin (βCD) 1: 1 inclusion complex. Methods: By studying the inclusion of β CD and nisoldipine solubility and solubility after inclusion, and the dissolution of β-CD inclusion compound of nisoldipine and API and PVP solid dispersible tablets were compared. Results: After the inclusion of nisoldipine, its solubility in water increased from 7.10μg · ml-1 before inclusion to 15.75μg · ml-1. Conclusion: The dissolution of clathrates is better than that of bulk drugs, but not as good as that of solid dispersions.