作为细胞毒类药物上市的第一个铂络合物是顺氯氨铂或顺二氯化二氨络铂,它对其他药物耐药的肿瘤有一定价值。但是它具有肾毒性、耳毒性,并可引起外周神经病变和胃肠道障碍,这限制了顺氯氨铂的治疗价值。Carboplatin是第一个第二代铂衍生物,已使用于临床,其毒性显著低于顺氯氨铂。 The first platinum complex to be marketed as a cytotoxic drug is cisplatin or cisplatin cisplatin, which is of value for other drug-resistant tumors. But it has nephrotoxicity, ototoxicity, and can cause peripheral neuropathy and gastrointestinal disorders, which limits the therapeutic value of cisplatin. Carboplatin is the first second-generation platinum derivative that has been used clinically and is significantly less toxic than cisplatin.