作者使用平均体重为200克的 Wistar 大鼠雌性133只,分组肌注丁胺卡那霉素15mg/kg,丁酰苷菌素15mg/kg,艮他霉素10mg/kg,卡那霉素15mg/kg,卡那霉素 B10mg/kg,妥布霉素5mg/kg 和西梭霉素3mg/kg 共7组。所选剂量均为人用的最大剂量,间隔12小时肌注一次,共4周。每天19:00-次日7:00禁食禁水收集尿液,测量尿液体积,进行细胞计数后计算每分钟肾小管上皮细胞排 The authors used 133 Wistar rats of average body weight of 200 g to receive intramuscular amikacin 15 mg / kg, budesin 15 mg / kg, gentamycin 10 mg / kg, kanamycin 15 mg kg / kg, kanamycin B 10 mg / kg, tobramycin 5 mg / kg, and sisamycin 3 mg / kg in total of 7 groups. The selected dose is the maximum dose for human use, intramuscular injection interval of 12 hours, a total of 4 weeks. Daily 19:00 - 7:00 the next day, fasting water collection urine collection, measurement of urine volume, after counting the number of cells per minute renal tubular epithelial cells