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目的研究阿奇霉素治疗小儿支气管肺炎的临床疗效。方法黄河三门峡医院采用注射用乳糖酸阿奇霉素治疗小儿支气管肺炎60例。阿奇霉素剂量按10mg/(kg.d),用0.9%氯化钠注射液或5%葡萄糖注射液配制成阿奇霉素浓度为1.0 mg/ml静脉滴注1~3h,疗程为5~7d。观察治疗前后症状、体征变化及外周血、肝功能、肾功能、X线胸片变化,并取咽部或上呼吸道分泌物做细菌培养及阿奇霉素药敏试验,或取上呼吸道分泌物及血清进行支原体等非典型病原菌抗原或抗体检测。结果痊愈26例,显效30例,好转4例,总有效率为93.3%。10例发生不良反应,占16.7%,其中纳差5例,恶心、腹痛3例,皮肤风团1例,静脉滴人处疼痛1例,停药1天后不良反应消失。结论乳糖酸阿奇霉紊治疗小儿支气管肺炎临床疗效好,安全性较高。
Objective To study the clinical efficacy of azithromycin in the treatment of bronchial pneumonia in children. Methods Sanmenxia Hospital of Yellow River injection of lactose azithromycin in children with bronchial pneumonia in 60 cases. Azithromycin dose according to 10mg / (kg.d), with 0.9% sodium chloride injection or 5% glucose injection azithromycin formulated as 1.0 mg / ml intravenous infusion of 1 ~ 3h, treatment for 5 ~ 7d. Observed before and after treatment of symptoms and signs and changes in peripheral blood, liver function, renal function, X-ray changes, and take the pharynx or upper respiratory secretions do bacterial culture and azithromycin susceptibility testing, or take the upper respiratory secretions and serum Mycoplasma and other atypical pathogens antigen or antibody detection. Result cured 26 cases, markedly effective in 30 cases, improved in 4 cases, the total effective rate was 93.3%. Adverse reactions occurred in 10 cases, accounting for 16.7%. Among them, there were 5 cases of anorexia, 3 cases of nausea and abdominal pain, 1 case of skin wind group, 1 case of intravenous drip and 1 case of adverse drug reactions. Conclusion Azithromycin lactobionate treatment of bronchial pneumonia in children with good clinical efficacy and safety.