论文部分内容阅读
目的探讨颅内动脉瘤蛛网膜下腔出血并心肌损伤与氧化应激反应的关系,以明确其发病机制,并据此寻找有效防治方法。方法取80只日本大耳白兔,按照改良胰弹性蛋白酶诱导动脉瘤方法制作动脉瘤模型,根据心肌酶谱、心电图变化等筛选心肌损伤动物,并据此分为心肌损伤组和非心肌损伤组,术后3周处死动物,酶联免疫吸附法测定2组术后心肌局部组织中超氧化物歧化酶(SOD)、基质金属蛋白酶-9(MMP-9)、丙二醛(MDA)含量,评估氧化应激反应对心肌损伤影响。结果心肌损伤组心肌组织局部SOD含量明显低于非心肌损伤组(P<0.05),MMP-9、MDA含量均明显高于非心肌损伤组(P均<0.05)。结论颅内动脉瘤合并心肌损伤动物心肌局部存在心肌氧化应激反应,导致心肌局部氧自由基清除障碍、心肌细胞膜脂质过氧化、细胞破坏等,可能是心肌损伤的原因之一。
Objective To explore the relationship between intracranial aneurysm subarachnoid hemorrhage and myocardial injury and oxidative stress in order to clarify its pathogenesis and to find effective prevention and treatment methods. Methods Totally 80 Japanese white rabbits were used to make the aneurysm model according to the modified pancreatic elastase-induced aneurysm. The animals were divided into myocardial injury group and non-myocardial injury group according to myocardial enzymes and electrocardiogram changes. The animals were sacrificed at 3 weeks after operation. The contents of superoxide dismutase (SOD), matrix metalloproteinase-9 (MMP-9) and malondialdehyde (MDA) in myocardial tissue were measured by enzyme-linked immunosorbent assay Effect of Oxidative Stress on Myocardial Injury. Results Compared with non-myocardial injury group, the content of SOD in myocardial tissue in myocardial injury group was significantly lower than that in non-myocardial injury group (P <0.05). Conclusions Myocardial oxidative stress exists in the myocardium of intracranial aneurysms combined with myocardial injury, resulting in the removal of oxygen free radicals in the myocardium, lipid peroxidation of myocardial cells and cell destruction, which may be one of the causes of myocardial injury.