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中科院上海巴斯德研究所钟劲研究组通过表达突变型的MAVS蛋白,构建了丙型肝炎(HCV)病毒感染可诱导固有免疫反应的新型细胞系,发现RIG-I并不是HCV病毒感染过程中的关键模式识别受体。相关研究成果已在线发表于《肝脏病学杂志》。HCV是人类的重要病原体,能够通过逃逸宿主的免疫防御系统来建立持续性感染,导致肝硬化和肝癌。病毒在感染过程中被宿主细胞的模式识别受体识别,从而激
Zhong Jin, Pasteur Institute, Shanghai Pasteur Institute, Chinese Academy of Sciences, constructed a new cell line capable of inducing an innate immune response to Hepatitis C virus (HCV) infection by expressing a mutant MAVS protein and found that RIG-I was not an HCV infection The key pattern recognition receptors. Relevant research results have been published online in the Journal of Hepatology. HCV is an important human pathogen that can establish a persistent infection by escaping the host’s immune defense system, leading to cirrhosis and liver cancer. The virus is recognized by the host cell’s pattern recognition receptor during infection, thereby stimulating it