早已知道苯胺染料如联苯胺和萘胺能导致人类膀胱癌。但苯胺及邻甲苯胺是否致癌仍有疑问。动物实验结果显示苯胺仅具弱致癌性,而邻甲苯胺有强致癌性;邻甲苯胺能致膀胱癌而苯胺则否。国际癌症研究中心(IARC)表明,邻甲苯胺盐酸盐对实验动物有致癌性,已观察到接触邻甲苯胺的工人膀胱癌发病率增高,但由于所有工人都接触其它可能致癌的化学品,尚不能确认邻甲苯胺是膀胱癌特异致癌物。在实际工作中应认为邻甲苯胺对人类有致癌风险。IARC认为,苯胺盐酸盐对实验动物有致癌性的证据有限。 Aniline dyes such as benzidine and naphthylamine have long been known to cause human bladder cancer. However, whether aniline and o-toluidine are carcinogenic is still in doubt. Animal experiments showed that aniline only weak carcinogenicity, and o-toluidine strong carcinogenic; o-toluidine can cause bladder cancer and aniline is not. The International Agency for Research on Cancer (IARC) has shown that o-toluidine hydrochloride is carcinogenic to laboratory animals and that workers with o-toluidine have been observed to have an increased incidence of bladder cancer, but because all workers have exposure to other potentially carcinogenic chemicals, Not yet confirmed o-toluidine is a specific bladder cancer carcinogens. In actual work, o-toluidine should be considered carcinogenic to humans. IARC believes there is limited evidence that aniline hydrochloride is carcinogenic to experimental animals.