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目的：研究激光角膜原住磨镶术（LASIK）前后国人角膜内皮细胞密度和形态的改变，方法：选择无配戴接触镜史的-6.00~－26．00D（-11.89±4.58D）高度近视患眼利眼进行LASIK治疗，按照角膜切削面距离角膜内皮层厚度分为两组，组1：28眼为200~250μm，组2：13眼为251~300μ，各组患眼于术前和术后第3、10天、1、3个月观察和分析角膜内皮的细胞密度、变异系数和六角形细胞百分比，结果：①各级术前、术后的角膜内皮细胞密度、变异系数或六角形细胞百分比差异均无显著性意义（P＞0.05）；②角膜内皮细胞密度、变异系数或六角形细胞百分比的改变与切削面距离内皮层厚度不存在统计学的相关性，结论：激光角膜原位磨镶术不引起中央部角膜内皮细胞密度和形态的改变，是矫正高度近视一种安全的屈光手术，对于以切削后切削面距离角膜内皮层厚度200μum作为安全性的指标尚需作进一步的论证。
Objective: To study the changes of corneal endothelial cell density and morphology before and after labyrinthine laser in situ keratomileusis (LASIK) .Methods: -6.00 ~ -26.00D (-11.89 ± 4.58D) high myopia According to the thickness of corneal endothelium, corneal cutting surface was divided into two groups according to the thickness of corneal cutting surface, which was 200 ~ 250μm in group 1, 28 and 251 ~ 300μ in group 2:13, The cell density, coefficient of variation and percentage of hexagonal cells in the corneal endothelium were observed and analyzed at the 3rd, 10th and the 3rd postoperative day. Results: ①The preoperative and postoperative corneal endothelial cell density, coefficient of variation or six (P> 0.05) .②The change of corneal endothelial cell density, coefficient of variation or percentage of hexagonal cells didn¡¯t statistically correlate with the distance from the cutting surface to the endothelium. Conclusion: Bit mill inlay does not cause the central part of the corneal endothelial cell density and morphological changes, is a safe correction of high myopia refractive surgery, cutting the cutting surface from the corneal endothelial cortex thickness 200μum as security The full range of indicators still need further evidence.