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对于类固醇逆转急性格林-巴利综合征、横贯性脊髓炎和多发性硬化患者的神经缺失能力是有争论的。因其治疗作用的不稳定和长期类固醇疗法的可能有害作用,许多神经病学家不愿意在这些疾病中使用糖皮质醇。在治疗脱髓鞘疾病中,影响类固醇疗效的因素可能与诸如类固醇总量、用药间歇时间、用药途径以及治疗前神经缺失的严重程度和病程等有关。作者给5例格林-巴利综合征、3例急性横贯性脊髓炎、7例急性多发性硬化,共15例患者尽可能早地进行了大剂量类固醇静脉治疗。开始2天每6小时甲基泼尼松龙600～1,000mg静脉冲击1次,然后改成口服强的松120mg/天,4次分服。口服大剂量强的松最少持续2周。第3周全日量于早晨一次服用。1月后,逐
There is debate about the ability of steroids to reverse acute Guillain-Barre syndrome, neurological deficits in patients with transverse myelitis and multiple sclerosis. Many neurologists are reluctant to use glucocorticoids in these diseases due to their unstable therapeutic effects and the potentially detrimental effects of long-term steroid therapy. In the treatment of demyelinating diseases, the factors that affect the efficacy of steroids may be related to such as the total amount of steroids, medication pause time, route of administration and the severity and duration of pre-treatment nerve loss and so on. The authors conducted a high-dose steroid intravenous therapy as early as possible in five patients with Guillain-Barre syndrome, three with acute transverse myelitis, and seven with acute multiple sclerosis. The first two days every 6 hours methylprednisolone 600 ~ 1,000mg intravenous 1, and then changed to oral prednisone 120mg / day, 4 times sub-service. Large doses of oral prednisone for at least 2 weeks. Week 3 full-day dose in the morning. After January, by