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干细胞治疗是缺血性心脏病治疗的一种新的治疗策略,是心血管疾病治疗研究的前沿。国内外大量研究显示出细胞移植能够修复受损心肌,减少梗死面积,改善心脏功能。但目前细胞治疗仍处于早期阶段,各种问题尚待解决,如种子细胞类型的选择、细胞分化、梗死区细胞存活、最佳移植途径、安全性等问题还需深入探讨。为此,现总结前期干细胞治疗基础及临床研究结果,就目前存在的问题进行阐述。
Stem cell therapy is a new therapeutic strategy for the treatment of ischemic heart disease and is at the forefront of cardiovascular disease research. A large number of studies at home and abroad show that cell transplantation can repair damaged myocardium, reduce infarct size and improve cardiac function. However, cell therapy is still at an early stage and various problems remain to be solved. For example, the selection of seed cell types, cell differentiation, cell survival in infarct area, optimal transplantation pathways, and safety issues need to be further explored. To this end, are summarized the basis of early stem cell therapy and clinical research results, the current problems described.