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目前公认食管鳞状上皮不典型增生是癌前期病变,可进展至癌。但对其恶性转化规律知之甚少。我们将内镜活检证实的食管良性增生和轻中度不典型增生组织进行胚胎型谷胱甘肽转移酶(GST-π)和P53免疫组化染色。对患者进行长达8年随访,观察食管鳞癌和重度不典型增生发病概率、筛选预后危险因素。
Currently recognized atypical esophageal squamous hyperplasia is precancerous lesions, can progress to cancer. However, little is known about its malignant transformation patterns. We performed endoscopic biopsy of esophageal benign hyperplasia and mild to moderate atypical hyperplastic tissues for embryonic glutathione transferase (GST-π) and P53 immunohistochemical staining. Patients were followed for up to 8 years to observe the incidence of esophageal squamous cell carcinoma and severe atypical hyperplasia, screening prognostic risk factors.