肺气肿的产生是由于弹性蛋白酶及其抑制剂之间的平衡失调所引起的肺实质弹力网状结构的破坏,尽管其发生与遗传、肺损伤、感染和营养不良等多种因素有关,但吸烟是造成肺气肿的主要危险因素。近年来对吸烟引起肺气肿的发病机理进行了比较深入的研究,本文着重从生物化学的角度作一概述。【吸烟对蛋白酶抑制剂的影响】肺分泌物中蛋白酶抑制剂的来源有五种:(1)上皮细胞产生;(2)粘膜下腺体分 Emphysema is caused by the destruction of the parenchymatous elastic reticular structure of the lung caused by the imbalance between elastase and its inhibitors. Although it occurs with a variety of factors such as heredity, lung injury, infection and malnutrition, Smoking is a major risk factor for emphysema. In recent years, the pathogenesis of smoking caused emphysema conducted a more in-depth study, this article focuses on the biochemistry from an overview. [Smoking on protease inhibitors] There are five sources of protease inhibitors in lung secretions: (1) epithelial cells; (2) submucosal glands