恶性症状群是抗精神病药物治疗中的一种可能致命的副作用。其特点表现为严重的肌强直、高热、和植物神经功能障碍。可因呼吸衰竭而死亡。长时间的肌强直常招致严重的横纹肌溶解从而产生肌红蛋白尿和最终产生急性肾功能衰竭。恶性症状群是很少见 Malignant syndrome is a potentially fatal side effect of antipsychotic treatment. It is characterized by severe myotonia, fever, and autonomic dysfunction. May be due to respiratory failure and death. Prolonged myotonia often results in severe rhabdomyolysis which produces myoglobinuria and ultimately acute renal failure. Vicious symptoms are rare