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先天性膈疝(CDH)是仅次于肺发育不良和呼吸衰竭的高死亡风险因素之一。在实验动物中,幼胎气管闭塞(TO)法可促进动物肺的生长及形态学成熟。作者对采用胎儿TO方法治疗重症CDH进行了随机实验,对纳入本研究的20例儿童的肺功能指标进行检测,[9例采用传统方法(对照组),11例采用TO方法]。假设TO 能够改善肺功能。在出生时,TO组的婴儿的平均胎龄较小(30.8±2.0周vs 37.4±1.0周,P=0.000 2)。所有婴儿需要辅助通气。两组间死亡率无差异TO组与对照组分别为64% vs 78%,P=0.64)。在以下4个时段对呼吸功能进行测定:①生后最初24 h;②在CDH修复
Congenital diaphragmatic hernia (CDH) is one of the high risk factors for death after lung dysplasia and respiratory failure. In experimental animals, bronchial obliteration (TO) method can promote the growth and morphological maturation of lung in animals. The authors conducted a randomized trial of fetal TO treatment of severe CDH in 20 children enrolled in this study for pulmonary function tests [9 patients in the traditional method (control group) and 11 patients in the TO method]. Suppose TO improves lung function. At birth, the average gestational age of infants in TO group was smaller (30.8 ± 2.0 weeks vs 37.4 ± 1.0 weeks, P = 0.000 2). All infants need assisted ventilation. No difference in mortality between the two groups TO and control groups were 64% vs 78%, P = 0.64). Respiratory function was measured in the following 4 sessions: ① first 24 hours after birth; ② after CDH repair