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分泌性中耳炎(OME)是引起儿童听力下降常见病因之一。许多学说曾被用以解释鼓室持续渗出,但目前尚无定论。作者设想持续的细菌抗原可能引起中性粒细胞(PMN)脱颗粒,导致中耳长期炎症。选用二种PMN粒蛋白-乳铁蛋白(Lf)和37型阳离子蛋白(CAP37)作为脱颗粒现象和局部炎症的标记,以观察OME中细菌抗原与PMN脱颗粒蛋白浓度的关系。作者选择了从3个月到8岁的27例(47耳)鼓室渗液患儿进行研究。有4耳(9%)培养出了病原菌:肺炎链球菌(S菌)和流感嗜血杆菌(H菌)各半。与此相反,分别有10耳(21%)和12耳(26%)检出S菌抗原和H菌抗原,还
Secretory otitis media (OME) is one of the common causes of hearing loss in children. Many theories have been used to explain the continued leaking out of the tympanic cavity, but there is no conclusion yet. The authors hypothesize that persistent bacterial antigens may cause neutrophil (PMN) degranulation, resulting in long-term inflammation of the middle ear. Two kinds of PMN-Lactoferrin (Lf) and 37-type Cationic Protein (CAP37) were selected as markers of degranulation and local inflammation to observe the relationship between bacterial antigen and PMN degranulation protein concentration in OME. The authors selected 27 patients (47 ears) with tympanic effusion from 3 months to 8 years of age. There are 4 ears (9%) of the pathogenic bacteria: Streptococcus pneumoniae (S) and Haemophilus influenzae (H) half. In contrast, S and H antigens were detected in 10 (21%) and 12 (26%) ears, respectively