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咪康唑(MZ)为咪唑类广谱抗真菌药,但并不是首选药。它的溶解性及胃肠道吸收差,导致生物利用度不规则和难以预测,其输液剂型受到起胶体稳定作用的聚氧乙烯蓖麻油的多种毒性作用的限制。本研究的目的是测试MZ能否通过与多种环糊精(CD)及其衍生物的复合而增加在水中的溶解度。方法
Miconazole (MZ) is a broad-spectrum antifungal agent for imidazole, but it is not the drug of choice. Its poor solubility and gastrointestinal absorption lead to irregular and unpredictable bioavailability and its infusion dosage forms are limited by the multiple toxic effects of polyoxyethylene castor oil, which acts as a colloid stabilizing agent. The purpose of this study was to test whether MZ can increase the solubility in water by complexing with a variety of cyclodextrins (CDs) and their derivatives. method