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本文以小鼠为材料,观察了29种药物主要为抗癌药物的延迟毒性反应规律,提出了一种简易的延迟毒性指数计算法。一、前言延迟毒性(Delayed toxicity,下简称延毒)是肿瘤细胞毒类药物特性之一。鼠、狗、猴以至人都可进行延毒研究。评价指标可以对血细胞如血小板、白细胞,或器官如肝、肾等的毒性。有的则用小鼠剂量死亡延续的时间描述延毒的强弱。这些评价指标虽然能从一个方面显示药物延毒的程度。但是,延毒的强弱却不能以概括性的数字予以表达,药物间延毒的强弱也就失去了比较的基础。小鼠对延毒反应灵敏,重现性较好,观察指标明确,实验周期短和经济等优点,是研究药物延毒反应较理想的动物。根据对29种药物小鼠延毒反应规律观察,各种延毒参数,指数值的“0”值测验和
In this paper, mice were used as materials to observe 29 drugs as the main anti-cancer drug delayed toxicity reaction law, and proposed a simple delay toxicity index calculation method. I. Introduction Delayed toxicity (hereinafter referred to as prolonged toxicity) is one of the characteristics of tumor cytotoxic drugs. Rats, dogs, monkeys and even people can carry out venom studies. The evaluation index can be toxic to blood cells such as platelets, white blood cells, or organs such as liver and kidney. Others describe the strength of antagonism by the time it takes for mice to die. Although these evaluation indicators can show the extent of drug toxicity from one aspect. However, the strength of prolonged poisoning cannot be expressed in terms of general figures, and the strength of drug prolongation between drugs loses the basis for comparison. The mice are sensitive to prolonged toxicity, good reproducibility, clear observation indicators, short experimental cycle, and economic advantages, and are ideal animals for studying the drug toxicity response. According to observations of the law of the poisoning response of 29 kinds of drug mice, various venom parameters, “0” value of the index value test and