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目的观察紫杉醇联合解毒饮对头颈部恶性肿瘤的近期疗效和毒副作用。方法选择51例头颈部恶性肿瘤患者选用紫杉醇与卡铂方案化疗,每4周重复用,共3~6周期,同时煎服解毒饮和静滴鱼腥草注射液。结果初治的19例患者中,CR 2例(10.5%),PR 6例(31.6%),RR为42.1%;复治的32例患者中,CR 2例(6.3%),PR 9例(28.1%),RR为34.4%;初治疗效优于复治。结论紫杉醇联合解毒饮对头颈部恶性肿瘤有较好的近期疗效,尤其对初治者效果更佳,而且毒副作用比较轻。
Objective To observe the short-term efficacy and toxic side effects of paclitaxel and Jieduyin on malignant tumors of head and neck. Methods A total of 51 patients with head and neck malignancy were treated with paclitaxel and carboplatin regimens. They were repeated every 4 weeks for a total of 3 to 6 cycles. At the same time, Jieduyin and Jingdi Houttuynia injection were decocted. Results Among the 19 newly diagnosed patients, 2 were CR (10.5%), 6 were PR (31.6%), and RR was 42.1%. Of the 32 patients retreated, 2 were CR (6.3%), and 9 were PR. 28.1%), RR was 34.4%; initial treatment effect was better than retreatment. Conclusion Paclitaxel combined with Jieduyin has a good short-term curative effect on malignant tumors of the head and neck, especially for the newly treated patients, and the side effects are lighter.