经典学说认为,偏头痛发作与脑血管痉挛以及随之而来的颅外血管扩张有关。近来,一些研究发现:偏头痛发作时脑血流量减少,以致脑细胞缺血、缺氧。而缺氧则引起钙内流,使大量钙离子进入脑细胞内,结果导致脑细胞功能障碍而产生偏头痛的各种先兆症状。基于这些新发现,钙通道阻滞剂已开始用于防治偏头痛。 The classic doctrine states that migraine attacks are associated with cerebral vasospasm and consequent extracranial vasodilation. Recently, some studies have found that cerebral blood flow decreases during migraine attacks resulting in ischemia and hypoxia of brain cells. Hypoxia causes calcium influx, so that a large number of calcium ions into the brain cells, leading to brain cell dysfunction and migraine caused by a variety of aura symptoms. Based on these new findings, calcium channel blockers have begun to be used to combat migraine.