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目的分析国内近5年肺孢子菌肺炎(pneumocystis pneumonia PCP)发病与诊疗状况,从而为PCP诊治提供参考。方法检索国内2008—2012年发表的有关PCP论文,并对文献中PCP的病例数、基础病、诊疗等情况进行分析。结果①共检索到PCP相关的文献报道298篇;②PCP患者共4153例,其中3518例(84.7%)PCP与HIV/AIDS相关,285例(6.9%)PCP患者与器官移植相关,恶性肿瘤相关PCP患者94例(2.3%),结缔组织病相关PCP 67例(1.6%),肾病综合征相关PCP患者16例(0.4%);③4 153例PCP患者中,3 006例提及诊断方法,其中1 785例(59.4%)为临床诊断,915例(30.5%)为染色发现病原体;④2 664例提及治疗,其中2 604例(97.7%)予以磺胺甲恶唑-甲氧苄啶(TMP-SMZ)或TMP-SMZ联合其他药物治疗。结论目前国内PCP患者的基础病主要是HIV感染,器官移植术后,恶性肿瘤,结缔组织病等,该病确诊比较困难,TMP-SMZ是目前治疗PCP的首选药物。
Objective To analyze the incidence and diagnosis and treatment of pneumocystis pneumonia PCP in recent 5 years in China and provide a reference for the diagnosis and treatment of PCP. Methods The papers about PCP published in China from 2008 to 2012 were retrieved and the number of cases, basic diseases, diagnosis and treatment of PCP in the literature were analyzed. Results ① A total of 298 articles were reported in the literature related to PCP. ②PCP patients were 4153 cases, of which 3518 cases (84.7%) were related to HIV / AIDS and 285 cases (6.9%) were related to organ transplantation and malignancy-associated PCP There were 94 patients (2.3%), 67 patients (1.6%) with connective tissue disease (PCP) and 16 patients (0.4%) with nephrotic syndrome-related PCP. ③ Of the 1533 PCP patients, 3 006 patients referred to the diagnosis method, of which 1 785 cases (59.4%) were clinically diagnosed and 915 cases (30.5%) were found to be pathogenic stains; (2) 664 cases were referred for treatment, of which 2 604 (97.7%) were treated with sulfamethoxazole-trimethoprim ) Or TMP-SMZ in combination with other medications. Conclusions At present, the basic diseases of PCP in China are mainly HIV infection, organ transplantation, malignant tumor and connective tissue disease. TMP-SMZ is the first choice for the treatment of PCP.