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目的观察复合膳食纤维对健康受试者血脂及碳水化合物代谢的影响。方法12例健康志愿者,男性3例,女性9例,年龄18～38岁,平均年龄(25.8±5.3)岁。分为无纤维试餐组及高纤维试餐组,每组6人。采用双周期、cross-over设计。按代谢动力学方法采集受试者摄入试餐后不同时间点的血样及呼气样本,进行血糖、血甘油三酯及13CO2的测定。受试者完成第I周期实验后,中间经过1周的洗脱期,两组受试者交叉,重复上述实验。结果两组血糖峰值、达峰时间、及餐后1h内曲线下面积均有统计学差异,高纤维试餐组明显低于无纤维试餐组;血糖的总曲线下面积,两组间无显著性差异。两组试餐餐后血甘油三酯峰高、餐后2～5h内血脂曲线下面及总曲线下面积有统计学差异,两组的达峰时间无统计学意义。两组呼气样本的DOB值在0.5、1.5、2.0、2.5、3.5、4.0h有显著性差异;6h内13CO2的累积回收率有显著差异,8h的13CO2的累积回收率两组无差异。结论本实验所用复合膳食纤维能够延迟膳食中碳水化合物的吸收并减少膳食中脂肪的吸收。
Objective To observe the effect of compound dietary fiber on blood lipid and carbohydrate metabolism in healthy subjects. Methods Twelve healthy volunteers, 3 males and 9 females, aged from 18 to 38 years and mean age (25.8 ± 5.3) years. Divided into no-fiber test group and high-fiber test group, 6 in each group. Dual-cycle, cross-over design. According to the method of metabolic dynamics, blood samples and expiratory samples of subjects at different time points after ingestion of test meal were collected for determination of blood glucose, triglycerides and 13CO2. Subjects completed the first cycle of the experiment, the middle after a week of elution period, the two groups of subjects crossed, repeat the above experiment. Results The peak blood glucose, the peak time and the area under the curve in 1h postprandial were significantly different between the two groups. The high fiber test group was significantly lower than the non-fiber test group. The area under the total curve of blood glucose was not significant between the two groups Sex differences. Blood glucose triglyceride peak height of the two groups after a meal test, within 2 ~ 5h postprandial blood lipid curve and the area under the total curve were statistically different, the peak time of two groups was not statistically significant. The two groups of breath samples DOB value at 0.5,1.5,2.0,2.5,3.5,4.0h significant difference; within 6h cumulative recovery 13CO2 significant difference, 8h 13CO2 cumulative recovery of two groups no difference. Conclusions The composite dietary fiber used in this experiment was able to delay carbohydrate absorption in the diet and reduce fat absorption in the diet.