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目的探讨高危型人乳头瘤病毒(HPV)感染与宫颈癌前病变以及宫颈癌的相关性。方法 120例宫颈癌或是癌前病变患者,其中60例为宫颈癌前病变患者(癌前病变组),60例为宫颈癌患者(宫颈癌组),将其归为观察组,同时期60例阴道炎宫颈无细胞学改变的患者设为对照组。采用宫颈液基细胞学检查法与宫颈刮片、免疫组化予以筛查分析,同时还采用达安PCR-反向点杂交法检测,对比分析各组检测结果。结果高危型HPV总阳性率为56.67%,癌前病变组、宫颈癌组以及对照组患者的高危型HPV阳性率分别为65%、95%、10%,三组患者的阳性率对比差异具有统计学意义(P<0.05)。结论高危型HPV感染与宫颈癌前病变以及宫颈癌具有非常密切的关系,而在高危型HPV感染中以HPV16感染为主。
Objective To investigate the relationship between high-risk human papillomavirus (HPV) infection and cervical precancerous lesions and cervical cancer. Methods 120 cases of cervical cancer or precancerous lesions, of which 60 cases of cervical precancerous lesions (precancerous lesions group), 60 cases of cervical cancer patients (cervical cancer group), will be classified as observation group, the same period 60 Cases of vaginal cervix without cytological changes in patients as a control group. Cervical liquid-based cytology and cervical smears were used for screening and analysis by immunohistochemistry, and Daan PCR-reverse dot blot hybridization method was also used to detect the results of each group. Results The positive rate of high-risk HPV was 56.67%. The positive rate of high-risk HPV was 65%, 95%, 10% respectively in precancerous lesions, cervical cancer and control groups. There was statistically significant difference between the three groups Significance (P <0.05). Conclusion High-risk HPV infection has a close relationship with cervical precancerous lesions and cervical cancer, while HPV16 infection is the main cause of high-risk HPV infections.