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血管内皮生长因子(Vascular endothelium growth factor,VEGF)最早于1989年由Ferrara等人分别在牛脑垂体滤泡星形细胞体外培养液中分离提纯,是一种对血管生长有强诱导作用并且是目前所知唯一特异地作用于血管内皮细胞的一种生长因子,同时由于VEGF具有增强血管通透性的功能,它又被称为血管通透因子(Vascular permeability factor,VPF)。VEGF广泛地分布于人和动物的脑、肾、肝、脾、肺及骨胳等组织,参与正常胚胎发育、卵泡成熟及肾脏等生理性调节,并在炎症、创伤愈合、心血管疾病及
Vascular endothelium growth factor (VEGF) was first isolated and purified by Ferrara et al. in bovine pituitary follicular astrocytes in vitro in 1989. It is a potent inducer of blood vessel growth and is currently The only known growth factor known to act on vascular endothelial cells, and because VEGF has the function of enhancing vascular permeability, it is also known as Vascular permeability factor (VPF). VEGF is widely distributed in the brain, kidney, liver, spleen, lungs, and bones of humans and animals. It participates in normal embryonic development, follicle maturation, and kidney physiological regulation, as well as inflammation, wound healing, and cardiovascular diseases.