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层粘连蛋白是细胞外基质和血管基底膜的主要组成成分,每一个层粘连蛋白分子都是含α、β、γ链的异源三聚体。被认识的层粘连蛋白分子已超过15种,分别由α1、α2、α3、α4、α5、β1、β2、β3、γ1、γ2、γ3以不同的组合方式构成。研究表明,层粘连蛋白在脑胶质瘤中表达增高,并在其生物学行为中起双刃剑作用,一方面,层粘连蛋白能促进胶质瘤细胞黏附和迁移,促进胶质瘤脑内侵袭,另一方面,层粘连蛋白参与抑制胶质瘤颅外转移屏障的构成。
Laminin is a major component of the extracellular matrix and vascular basement membrane, and each laminin molecule is a heterotrimer containing alpha, beta, gamma chains. More than 15 laminin molecules have been identified, which are composed of different combinations of α1, α2, α3, α4, α5, β1, β2, β3, γ1, γ2 and γ3, respectively. Studies have shown that laminin expression increased in gliomas and double-edged sword in its biological behavior, on the one hand, laminin can promote glioma cell adhesion and migration, promote glioma brain Invasion, on the other hand, laminin involved in inhibiting the composition of the extracranial metastatic barrier of glioma.