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关于3-氯丙二醇及2,3-氧丙醇的抗生育作用曾多次被证实,它们主要作用于副睾,影响精子受精能力,具有避孕起效快、恢复快的特点,但由于副作用还存在,未能运用于临床。据本文作者的报道,二者合并用药有减少单独用药量及副作用,并保持其原有避孕效果的作用。并提出3-氯丙二醇5 mg/kg/天×2加2,3-氧丙醇75mg/kg/天×2有较满意的抗生育效果,有效避孕天数多在14天左右,最少的避孕天数是10天。
The antifertility effects of 3-chloropropanediol and 2,3-oxopropanol have been confirmed several times. They mainly act on the epididymis and affect sperm fertility. They have the characteristics of rapid onset of contraception and quick recovery, but due to side effects Exist, failed to apply to the clinic. According to the report of the author of this article, the combination of the two drugs has the effect of reducing the amount and side effects of individual drugs and maintaining their original contraceptive effect. It was also proposed that 3-chloropropanediol 5 mg/kg/day×2 plus 2,3-oxopropanol 75 mg/kg/day×2 had satisfactory anti-fertility effects, and the effective number of days for contraception was about 14 days, and the minimum number of contraception days was minimum. It is 10 days.