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目的研究及观察膀胱癌患者围术期血清及尿液透明质酸(HA)、碱性成纤维细胞生长因子(b FGF)及血管内皮生长因子(VEGF)的变化情况。方法选取2013年1月至2014年7月收治并进行手术治疗干预的31例膀胱癌患者为观察组,并将同时间段的31例体检显示机体健康的同龄者选为对照组,然后分别于术前1 d及术后1、3、7、10、14 d时将观察组的血清及尿液HA、b FGF及VEGF指标进行检测,并检测对照组的上述指标,然后对检测结果进行分析及比较。结果观察组术前1 d及术后1、3、7 d的血清及尿液HA、b FGF及VEGF均高于对照组,且观察组术后10、14 d的血清及尿液HA及VEGF水平仍高于对照组,观察组术后3、7、10、14 d的血清及尿液HA、b FGF及VEGF水平均低于术前1 d及术后1 d(P均<0.05)。结论膀胱癌患者围术期血清及尿液HA、b FGF及VEGF波动较大,其均呈现持续降低的趋势,应给予针对性的干预。
Objective To study the changes of perioperative serum and urine hyaluronic acid (HA), basic fibroblast growth factor (b FGF) and vascular endothelial growth factor (VEGF) in patients with bladder cancer. Methods Thirty-one patients with bladder cancer admitted to our hospital from January 2013 to July 2014 were selected as the observation group and 31 healthy people of the same age who were examined by physical examination at the same time were selected as the control group. The indexes of HA, b FGF and VEGF in the serum and urine of the observation group were detected on the first day before operation and on the 1st, 3rd, 7th, 10th, 14th, 14th and 14th day after the operation. The above indexes of the control group were detected, and then the test results were analyzed And compare. Results The serum and urine HA, b FGF and VEGF in the observation group at 1 d before operation and at 1, 3 and 7 days after operation were significantly higher than those in the control group. Serum and urine HA and VEGF The levels of serum HA and b FGF and VEGF in the observation group at 3, 7, 10 and 14 days after operation were both lower than those at 1 day and 1 day after operation (all P <0.05). Conclusion Perioperative serum and urinary HA, b FGF and VEGF in bladder cancer patients fluctuate greatly, which show a trend of decreasing. Perioperative intervention should be given.