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目的：探讨索它洛尔的稳态血药浓度及其稳态药动学特征。方法：10例室性期前收缩者口服索它洛尔，分别为106／mg／d（n＝5）和240mg／d（n＝5），连服11剂。160mg／d组在每次用药后3h、两组均于末剂后0、3、4．5、6．5、9、12、16、24、36h测血药浓度。结果：服药第7剂后血药浓度达稳态，稳态血药浓度的峰值和谷值均与体重剂量呈线性正相关（r＝0．846或0．734，P＜0．05）。160mg／d组T1／2β为（18．18±6．32）h，VC／F为（1．81±0．34）L／kg；240mg／ d组分别为（13．27±2．46）h和（2．14±0．55）L／kg。结论：药-时曲线符合二房室开放模型；稳态血药浓度峰值和谷值与体重剂量呈正相关；体内药量一定时，血药浓度波动不大。
Objective: To investigate the steady-state plasma concentration of sotalol and its steady-state pharmacokinetic characteristics. Methods: Ten cases of ventricular discomfort were preterm ventricular contractions, with 106 / mg / d (n = 5) and 240 mg / d (n = 5), respectively. 160mg / d group 3h after each treatment, the two groups were measured after the last dose of 0,3,4.5,6.5,9,12,16,24,36 h plasma concentration. Results: After administration of the seventh dose, the plasma concentration reached a steady state. The peak and the trough of the steady state plasma concentration were positively correlated with the body weight dose (r = 0.846 or 0.734, P <0.05). T1 / 2β in 160mg / d group was (18.18 ± 6.32) h and VC / F was (1.81 ± 0.34) L / kg in group 160mg / d and (13.27 ± 2.46 ) H and (2.14 ± 0.55) L / kg. Conclusion: The drug-time curve accords with the two-compartment open model. The steady-state plasma concentration peaks and troughs are positively correlated with the body weight dose. When the drug dose is constant in vivo, the plasma concentration fluctuates little.