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目的应用meta分析的方法对各项研究进行系统分析以研究鱼的摄入与肾癌发病风险关系。方法在PubMed,Embase,CNKI,CA中检索有关鱼及其产品的摄入与肾癌关系的病例对照研究以及队列研究的文献。通过meta分析方法研究鱼的摄入与肾癌的关系。运用I~2检验各项研究的异质性,并使用漏斗图检验发表偏倚。结果共纳入17篇文献,采用随机效应模型合并分析后的结果未发现鱼的摄入与肾癌的发病风险相关(RR=0.90;95%CI,0.78～1.02)且异质性明显(P=0.003,I~2=52.3%),针对研究类型、研究地区以及发表时间进行亚组分析,同样没有明显的证据证明两者相关,但在性别亚组的分析中发现,男性增加鱼的摄入可降低肾癌的发病率,而在女性中则没有关系。结论 meta分析结果提示增加鱼的摄入未发现有预防肾癌发病的作用。
Objective To analyze the relationship between fish intake and the risk of renal cell carcinoma by meta-analysis. Methods A case-control study of the association between fish and their products intake and renal cell carcinoma was searched in PubMed, Embase, CNKI, CA and cohort studies. The relationship between fish intake and renal cell carcinoma was studied by meta-analysis. Heterogeneity of each study was tested using I ~ 2 and funnel plot was used to test publication bias. Results A total of 17 articles were included. The results of the randomized model analysis showed no correlation between the fish intake and the risk of renal cell carcinoma (RR = 0.90; 95% CI, 0.78-1.02) and the heterogeneity was significant (P = 0.003, I ~ 2 = 52.3%). There was also no clear evidence of subgroup analysis for the type of study, study area and time of publication, but analysis of the gender subgroup found that men increased fish intake Can reduce the incidence of kidney cancer, but in women it does not matter. Conclusion The results of meta-analysis suggest that increasing fish intake did not find any effect on the prevention of renal cell carcinoma.