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建立红外光谱法测定复方枸橼酸阿尔维林软胶囊中西甲硅油的含量。选用正己烷萃取西甲硅油,根据聚二甲基硅氧烷在1260cm~(-1)波数处Si—CH_3基团的对称变形振动有特征吸收峰,使用红外光谱波数为1330—1180cm~(-1),分辨率:2.0cm~(-1),狭缝:宽,响应:快;温度:25℃;相对湿度:50%。在选定的分析条件下,系统适用性、精密度和稳定性良好;西甲硅油在1.0-24.0mg·mL~(-1)浓度范围内呈良好线性关系(r=0.9965);加标回收率为100.79%(RSD=1.68%,n=9);3批样品含量测定结果分别为标示量的98.70%、97.93%、98.58%。该法简便、快速、专属性强、精密度高.适用于复方枸橼酸阿尔维林软胶囊中西甲硅油的含量测定。
Determination of Simethicone in Compound Alverine Soft Capsules by Infrared Spectroscopy. In this paper, n-hexane was used to extract simethicone oil. According to the symmetrical deformation vibration of Si-CH_3 group at 1260cm -1 wave number, polydimethylsiloxane had the characteristic absorption peak. The infrared wave number was 1330-1180cm -1 ), Resolution: 2.0cm -1, Slit: Wide, Response: Fast; Temperature: 25 ℃; Relative Humidity: 50%. Under the selected analysis conditions, the system has good applicability, precision and stability. Simethicone has a good linearity (r = 0.9965) in the range of 1.0-24.0 mg · mL -1. The spiked recoveries Was 100.79% (RSD = 1.68%, n = 9). The results of three batches of samples were 98.70%, 97.93% and 98.58% respectively of the labeled amount. The method is simple, rapid, specific and precise.It is suitable for the determination of simethicone in compound Alverine citrate soft capsule.