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在青霉素的早期研究中已报道过细菌置于一些抗生素环境中以后,细菌的恢复期延长了。这个现象在大多数抗生素的体外试验中已被肯定,并已用各种方法在体内得到证实。在体外抗生素后效作用(PAE)测定中目的是转移受到伤害的但仍然活着的细菌于不含药物的培养基中。许多方法诸如稀释含抗生素的培养物的方法,但此法并不能保证已没有抗生素活性被存留下来,鉴于部份抑制作用,其中一些反映在细菌形态的变化
In earlier penicillin studies it has been reported that bacterial recovery time is prolonged after exposure to some antibiotic conditions. This phenomenon has been confirmed in in vitro tests of most antibiotics and has been demonstrated in vivo in various ways. The purpose of the in vitro antibiotic efficacy (PAE) assay is to transfer injured but still alive bacteria in drug-free medium. Many methods, such as dilution of antibiotic-containing cultures, do not guarantee that no antibiotic activity has been retained, some of which are reflected in changes in bacterial morphology in view of partial inhibition