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对大脑过长时间的电刺激,因其可能对脑产生神经性损伤,限制了这种方法在医疗和实验中的应用。我们选用各种电极研究两个刺激参量——电荷密度和每相电荷量的相互作用,以确定电刺激引起的神经性损伤的临界值。刺激表面积为0.002～0.5cm~2的铂电极,植入成年猫的顶骨下皮层。穿透性铱微电极,刺激表面积为65±3×10~(-6)cm~2,插入顶骨下皮层,十天后对电极施加持续7小时的脉冲,该脉冲
Electrical stimulation of the brain for an extended period of time limits its application to medicine and experimentation because of its potential neurogenic damage to the brain. We used a variety of electrodes to study the interaction of two stimulation parameters, the charge density and the charge per phase, to determine the critical value of electrical nerve damage caused by electrical stimulation. Stimulate the platinum electrode with a surface area of 0.002 ~ 0.5cm ~ 2 and implant the parietal subcortical cortex of adult cats. The penetrating iridium microelectrode had a stimulating surface area of 65 ± 3 × 10 -6 cm 2 and was inserted into the parietal subcortical layer. Ten days later, a pulse lasting 7 hours was applied to the electrode. The pulse