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建立了食品接触材料中三乙醇胺迁移量的液相色谱-串联质谱法(LC-MS/MS)测定方法。食品接触材料浸泡液以氨基柱BEH Amide(50 mm×2.1 mm,1.7μm)作为分离色谱柱,以乙腈-水溶液为流动相,采用梯度洗脱的方式分离,在电喷雾离子源下以多反应监测(MRM)模式进行检测,外标法定量。在优化的条件下,三乙醇胺在5.0~100μg/L范围内线性关系良好,相关系数大于0.999,检出限(LOD,S/N=3)和定量限(LOQ,S/N=10)分别可达1.0和5.0μg/kg。在低、中、高3个水平加标浓度下的回收率为97.6%~100.8%,相对标准偏差(RSD)为0.7~1.7%,本方法简单方便、快速灵敏、准确可靠,可满足相关检测需求。
A liquid chromatography-tandem mass spectrometry (LC-MS / MS) method was developed for the determination of triethanolamine migration in food contact materials. The soaking liquid of food contact material was separated by gradient elution with a mobile phase of acetonitrile-water with a column of BEH Amide (50 mm × 2.1 mm, 1.7 μm) as the separation column. The electrospray ionization source Monitoring (MRM) mode for testing, external standard quantitative. Under optimized conditions, the linearity of triethanolamine in the range of 5.0-100 μg / L was good with a correlation coefficient of greater than 0.999. The limits of detection (LOD, S / N = 3) and the limits of quantitation (LOQ, S / N = 10) Up to 1.0 and 5.0 μg / kg. The recoveries were 97.6% -100.8% with RSD of 0.7-1.7% at low, medium and high levels. The method is simple, rapid, sensitive, accurate and reliable, and can meet the requirements of related tests demand.