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~(99m)Tc-HMDP是骨的核素显像剂,具有在骨骼中浓集度高和显像清晰的特点。对原发性及继发性的骨肿瘤或骨质代谢病变,由于具有在血和肌肉内的放射性本底低,通过显像都能获得清晰的图像,临床诊断具有重要意义和价值。为此我们进行了HMDP的合成,用~(99m)Tc进行标记,并对标记化合物进行放射化学纯度鉴定。 HMDP的化学名称为羟甲叉二膦酸二钠盐:Hydroxymethylene sodium diphosphonate,
~ (99m) Tc-HMDP is a bone nuclide imaging agent with high concentration in bone and clear imaging. For primary and secondary bone tumors or bone metabolism lesions, due to the low radioactive background in the blood and muscle, clear imaging can be obtained by imaging, clinical diagnosis of great significance and value. For this purpose, we carried out the synthesis of HMDP, labeled with ~ (99m) Tc and identified the radiochemical purity of the labeled compounds. The chemical name of HMDP is oxycodinium diphosphonate disodium salt: Hydroxymethylene sodium diphosphonate,