嗜碱粒细胞活化可释放胞内炎症介质组胺,上调其膜上蛋白分子CD63和CD203c等的表达。胞膜CD63和CD203c作为嗜碱粒细胞活化标记蛋白已被广泛应用,但近年发现,不同处理因素如某些信号分子特异的激动剂或阻断剂对膜上CD63和CD203c表达的影响并不同,且胞膜CD63和CD203c的表达与组胺释放也存在不一致。因此,视不同条件,选择或联合检测胞膜CD63、CD203c和组胺可全面评估嗜碱粒细胞活化情况。 Activation of basophils can release histamine, an intracellular inflammatory mediator, and upregulate the expression of membrane protein molecules such as CD63 and CD203c. Membrane CD63 and CD203c as basophils activation marker protein has been widely used, but in recent years found that different treatment factors such as certain signal-specific agonists or blockers on the membrane of CD63 and CD203c expression is different, And the expression of membrane CD63 and CD203c and histamine release also exist inconsistencies. Therefore, basophil activation can be fully evaluated by selection or co-assay of the membrane CD63, CD203c, and histamine, depending on the conditions.