人类肺发育起始于胚胎早期的原始肺芽,一直持续到出生后。胚胎期肺内液体的存在对肺的发育有重要意义,然而这些液体经过肺上皮的转运机制尚不完全清楚。水通道蛋白(aquaporin,AQP)被认为是通过渗透压和静水压差使水快速跨膜转运的一类特殊蛋白。AQPs在多种动植物组织中均有表达,在人、 Human lung development begins in the primitive lung bud early in the embryo and persists until after birth. The presence of fluid in the embryonic lung is important for the development of the lungs. However, the transport mechanism of these fluids through the lung epithelium is not fully understood. Aquaporin (AQP) is considered to be a special type of protein that transports water rapidly across the membrane through osmotic and hydrostatic pressure differences. AQPs are expressed in many animal and plant tissues,