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从1987年11月至1989年6月,我科收治急性早幼粒细胞白血病(APL)13例,用全反式维甲酸(RA)治疗后,除1例用药2天死于DIC外,均取得了较好的效果。但RA如何应用更为合理,如诱导分化时的剂量及完全缓解(CR)后如何用药等问题值得探讨。现结合我们的体会讨论如下。材料与方法 12例中男7例,女5例。年龄8～60岁。入院时10例有明显的出血倾向,7例有发热感染,8例重度贫血,4例胸骨压痛,2例肝肿大,1例
From November 1987 to June 1989, 13 cases of acute promyelocytic leukemia (APL) were treated in our department. After all-trans retinoic acid (RA) treatment, except 1 case died of DIC in 2 days, Achieved good results. However, how to use RA more reasonable, such as induction of differentiation dose and complete remission (CR) how to treat such issues worth exploring. Now with our experience discussed below. Materials and Methods In 12 cases, there were 7 males and 5 females. Age 8 to 60 years old. 10 cases had obvious bleeding tendency on admission, 7 cases had fever infection, 8 cases of severe anemia, 4 cases of sternal tenderness, 2 cases of hepatomegaly, and 1 case of hepatomegaly