【摘 要】
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We isolated cucurbitacin Ⅱa from the rhizomes of Hemsleya pengxianensis,and tested the cytotoxicity of cucurbitacin Ⅱa against various cancer cell lines by th
【机 构】
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School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan
论文部分内容阅读
We isolated cucurbitacin Ⅱa from the rhizomes of Hemsleya pengxianensis,and tested the cytotoxicity of cucurbitacin Ⅱa against various cancer cell lines by the sulforhodamine B assay (SRB).At the same time,we preliminarily found that cucurbitacin Ⅱa has a certain inhibitory activity on kinase CDK1/cyclin B,and shows potent inhibitory activities against many cancer cell lines.The cucurbitacin Ⅱa was structurally characterized by specific optical rotation measurement,high-resolution mass spectroscopy and NMR spectroscopic analysis.In addition,the molecular structure of cucurbitacin Ⅱa was further determined by X-ray single-crystal crystallography.
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