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【目的】探讨舒芬太尼与芬太尼在腹腔镜手术患者中的麻醉效果及并发症发生率，寻求更加合理的用药选择。【方法】将2013年1～12月在本院进行腹腔镜手术的400例患者随机分为两组（n ＝200）：试验组使用舒芬太尼麻醉，对照组使用芬太尼麻醉。统计分析两组患者心率、收缩压、舒张压、麻醉苏醒时间、呼吸恢复时间、麻醉清醒时间、镇痛效果、术后恶性呕吐情况。【结果】试验组麻醉苏醒时间、呼吸恢复时间、麻醉清醒时间均比对照组缩短，两组比较差异有统计学意义（均 P ＜0．05），舒芬太尼的镇痛效果明显优于芬太尼，两组比较差异有统计学意义（ P ＜0．05）；试验组的心血管系统及血流动力学指标的稳定性明显好于对照组（均 P ＜0．05）。试验组发生恶心呕吐9例，对照组发生恶心呕吐14例，两组比较差异无统计学意义（χ2＝1．15，P ＞0．05）；两组患者在麻醉前心率、收缩压、舒张压比较差异无统计学意义（ P ＞0．05），但麻醉后比较差异均有统计学意义（均 P ＜0．05）。【结论】舒芬太尼同样适用于腹腔镜手术的麻醉，其麻醉效果明显优于芬太尼，同时能够更好地维持患者心血管系统及血流动力学指标的稳定，并发症少，可以在临床推广使用。“,”Objective] To compare the anesthetic outcomes of sufentanil versus fentanyl during laparosco ‐py so as to seek a more reasonable drug selection .[Methods] During January‐December 2013 ,a total of 400 laparoscopic operations were randomly divided into two groups of experiment (sufentanil) and control (fenta‐nyl) ( n = 200 each) .Statistical analyses were conducted for heart rate (HR) ,systolic blood pressure (SBP) , diastolic blood pressure (DBP) ,anesthetic recovery time ,breathing recovery time ,anesthetics time ,analgesia and postoperative onsets of nausea and vomiting .[Results] Anesthetic recovery time ,breathing recovery time and anesthetic time were higher in experiment group than those in control group .And there were significant inter‐group differences ( P 0 .05) . There were statistically significant inter‐group differences in post‐anesthesia HR ,SBP and SBP ( P < 0 .05) . The stabilities of cardiovascular system and hemodynamics were significantly better in experiment group than those in control group .[Conclusion] Anesthesia with sufentanil is equally applicable to laparoscopic operation . And its anesthetic effect is obviously better than that of fentanyl and there are fewer complications .