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目的探讨内皮素1(ET-1)及其受体(ETAR与ETBR)在良性前列腺增生(BPH)移行区组织中表达的意义。方法采用免疫组化及Western blot技术检测5例正常前列腺组织(NP)与16例良性前列腺增生组织中ET-1及其受体表达。结果良性前列腺移行区组织中ET-1与ETAR表达明显高于正常前列腺组织。结论ET-1及其ETAR参与了良性前列腺增生的病理生理过程。
Objective To investigate the significance of the expression of endothelin-1 (ET-1) and its receptors (ETAR and ETBR) in the tissues of benign prostatic hyperplasia (BPH) transitional zone. Methods Immunohistochemistry and Western blot were used to detect the expression of ET-1 and its receptor in 5 cases of normal prostatic tissue (NP) and 16 cases of benign prostatic hyperplasia (BPH). Results The expression of ET-1 and ETAR in benign prostatic tissue was significantly higher than that in normal prostatic tissue. Conclusion ET-1 and ETAR are involved in the pathophysiological process of benign prostatic hyperplasia.