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[目的]观察蠲痹泻肺方联合西药治疗结缔组织病早期肺动脉高压疗效。[方法]使用随机平行对照方法,将62例住院/门诊患者按就诊顺序号方法简单随机随为两组。对照组30例硝苯地平,10mg/次,2次/d;若不耐受,改用卡托普利,25mg/次,2次/d。治疗组32例蠲痹泻肺方(黄芪、五爪龙各30g,南蛇藤20g,青风藤30g,穿山龙15g,防己10g,秦艽15g,丹参20g,莪术、桑白皮、地骨皮15g,葶苈子5g,茯苓30g,大枣、甘草各10g),1剂/d,水煎200m L,早晚温服;西药治疗同对照组。连续治疗12周为1疗程。观测临床症状、静息肺动脉收缩压(PASP)、6min步行距离(6mwd)、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈8例,显效19例,无效5例,总有效率84.40%;对照组痊愈4例,显效12例,无效14例,总有效率53.30%;治疗组疗效优于对照组(P<0.05)。PASP、6min步行距离两组均有改善(P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]蠲痹泻肺方联合西药治疗结缔组织病早期肺动脉高压,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Tongbixiefei Recipe combined with western medicine on early pulmonary hypertension in patients with connective tissue disease. [Methods] Using randomized parallel control method, 62 inpatients / outpatients were randomly assigned to two groups according to the sequence number of visiting doctor. Control group 30 patients nifedipine, 10mg / time, 2 times / d; if not tolerated, switch to captopril, 25mg / time, 2 times / d. In the treatment group, 32 cases of Pi Bi Xie Lung (Astragalus membranaceus, 30 g Agkistrodon, 20 g of Celastrus orbiculatus, 30 g of Aphis giganteum, 15 g of Rhodiola rosea, 10 g of Rhizoma Coptidis, 15 g of Radix Gentianae, 20 g of Radix Salviae Miltiorrhizae, , 葶 苈 子 5g, Poria 30g, jujube, licorice 10g), 1 / d, decoction 200m L, morning and evening warm clothes; western medicine treatment with the control group. Continuous treatment for 12 weeks for a course of treatment. Clinical symptoms, resting pulmonary artery systolic pressure (PASP), 6-minute walking distance (6 mwd), and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 8 cases were cured, 19 cases were markedly effective, 5 cases were ineffective, and the total effective rate was 84.40%. In the control group, 4 cases were cured, 12 cases markedly effective, 14 ineffective and the total effective rate was 53.30% (P <0.05). PASP, 6min walk distance improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.05, P <0.01). [Conclusion] Bi Bi Xie Lung combined with Western medicine in the treatment of early pulmonary hypertension of connective tissue disease, satisfactory results, no serious adverse reactions, it is worth promoting.