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使用气相色谱／质谱研究了人体尿中的川芎嗪代谢物，证实主要代谢物为３，５，６－三甲基吡嗪甲酸。
Gas chromatography/mass spectrometry was used to study the tetramethylpyrazine metabolites in human urine, and the main metabolite was confirmed to be 3,5,6-trimethylpyrazinecarboxylic acid.