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炎症介质在急性呼吸窘迫综合征等疾病过程中有重要作用。炎症介质mRNA稳定性的调控是RNA调控的一个重要方面。mRNA稳定性调控是一种广泛存在而极为重要的转录后调控方式,mRNA稳定与否直接关系到相应炎症介质表达量的多少。mRNA脱腺苷化是众多mRNA降解起始的开始和限速步骤,直接决定了mRNA稳定性的高低。mRNA脱腺苷并降解的调控途径众多,目前已知的主要有富含AU序列介导、无义介导、微小RNA介导、主要编码区域决定簇介导的途径和mRNA的缓慢脱腺苷途径,在不同细胞、不同环境中占据主导地位的调控途径存在差异。
Inflammatory mediators play an important role in diseases such as acute respiratory distress syndrome. Regulation of inflammatory mediators mRNA stability is an important aspect of RNA regulation. Regulation of mRNA stability is a widespread and extremely important post-transcriptional regulation, mRNA stability is directly related to the amount of expression of the corresponding inflammatory mediators. Adenosination of mRNA is the start and rate-limiting step of many mRNA de- viations and directly determines the level of mRNA stability. mRNA adenosine and degradation of many regulatory pathways, there are currently known to be rich in AU sequence-mediated, nonsense-mediated, microRNA-mediated, the main coding region of the determinant-mediated pathway and mRNA of the slow adenosine Pathways, in different cells, different environments dominate the way of regulation there are differences.