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目的研究大鼠去卵巢后股骨近端生物力学性能的变化。方法用切除雌性大鼠卵巢的方法建立骨质疏松模型,术后8周取出大鼠右侧股骨,测定股骨近端有关生物力学指标。结果生物力学检测显示,两组标本的最大载荷及刚度(结构力学指标)差异无统计学意义(P>0.05),但模型组标本的最大正应力(材料力学指标)显著下降(P<0.01)。结论雌性大鼠去卵巢8周后形成了骨质疏松。材料力学是评估模型动物骨质疏松较为灵敏的指标。
Objective To study the changes of biomechanical properties of proximal femur in ovariectomized rats. Methods The ovariectomized female rats were used to establish the model of osteoporosis. The right femur was removed 8 weeks after operation and the biomechanical parameters of the proximal femur were measured. Results Biomechanical tests showed that there was no significant difference in maximum load and stiffness (structural mechanics) between the two groups (P> 0.05), but the maximum normal stress (material mechanics index) of the model group decreased significantly (P <0.01) . Conclusion Female rats developed osteoporosis after ovariectomized for 8 weeks. Material mechanics is a more sensitive index to evaluate the model animal osteoporosis.