论文部分内容阅读
目的:探讨肿瘤标志物CA125与特发性炎症性肌病合并心包积液的关系。方法:回顾性分析217例特发性炎症性肌病患者,依据CA125水平分为CA125异常组及正常组,并运用心脏彩超测量心包积液,观察两组研究对象的一般信息、临床表现及心包积液情况,运用logistic回归分析CA125水平与心包积液的相关性。结果:217例特发性炎症性肌病患者中,CA125异常者59例(27.2%),心包积液者9例(15.3%);与正常组相比,CA125异常组心包积液差别存在统计学意义(P=0.017),且其总蛋白、白蛋白水平较低,尿素、肌酐水平升高,差异具有统计学意义(P<0.05);logistics回归分析提示CA125水平与心包积液呈正相关(OR=1.136,P=0.041;95%CI(1.048～9.246))。结论:特发性炎症性肌病合并心包积液并不少见,且与CA125密切相关。
Objective: To investigate the relationship between the tumor marker CA125 and idiopathic inflammatory myopathies with pericardial effusion. Methods: A total of 217 patients with idiopathic inflammatory myopathies were retrospectively analyzed. CA125 levels were divided into CA125 abnormal group and normal group. Pericardial effusion was measured by echocardiography. The general information, clinical manifestations and pericardial Effusion, the use of logistic regression analysis of CA125 levels and pericardial effusion correlation. Results: Of the 217 patients with idiopathic inflammatory myopathies, 59 (27.2%) had CA125 abnormalities and 9 (15.3%) had pericardial effusion. Compared with the normal group, there was statistical difference in the CA125 abnormal group (P = 0.017). The levels of total protein, albumin, urea and creatinine were significantly higher in the group with statistical significance (P <0.05). Logistic regression analysis showed that CA125 level was positively correlated with pericardial effusion OR = 1.136, P = 0.041; 95% CI (1.048 ~ 9.246)). Conclusion: Idiopathic inflammatory myopathies with pericardial effusion are not uncommon and closely related to CA125.