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人或动物在受致死性辐射损伤后,移植骨髓是使淋巴组织和免疫系统功能重建的重要措施之一。胸腺是中枢淋巴器官,移植骨髓后胸腺重建如何,直接关系到机体的细胞免疫机能。关于移植骨髓后的胸腺重建,人们虽早已注意到供体的种系不同会产生明显的效果差别,但其发生机理还很不清楚。为此我们着重观察小鼠受致死照射并移植不同品系小鼠的骨髓后,胸腺重建过程中的动态组织结构变化。材料与方法实验动物为非近亲繁殖的LACA小鼠和上海小鼠,均为雄性,10周龄。以LACA小鼠作受体,供体则分别用LAGA和上海两种-品系。照射源为钴-60,剂量为1000拉德,剂量率为91.5～89.5伦/分。受体在照后移
Bone marrow transplantation is one of the important measures to reconstruct the function of lymphoid tissues and the immune system after human or animal damage by lethal radiation. Thymus is a central lymphoid organ, and how the thymus is reconstructed after the transplantation of bone marrow is directly related to the cellular immune function of the body. With regard to thymus reconstruction after bone marrow transplantation, although people have long noticed that there are obvious differences in the effects of different donor lines, the mechanism is still unclear. To this end, we focus on observation of mice irradiated by lethal irradiation and transplantation of bone marrow of different strains of mice, dynamic tissue structure changes during thymus reconstruction. MATERIALS AND METHODS Experimental animals were non-inbred LACA mice and Shanghai mice, all male, 10 weeks old. LACA mice as acceptors, donors were used LAGA and Shanghai two strains - respectively. The irradiation source is Cobalt-60, the dose is 1000 rad, and the dose rate is 91.5-89.5 Lun / min. Recipients move backwards