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目的生物芯片分析作为新兴的现代毒理学研究技术之一,弥补和克服了传统毒理学的不足,可以快速、高通量地对毒物暴露信息进行处理,并根据毒物暴露信息的差异性分析筛选毒物作用敏感靶目标。生物芯片包括基因芯片、蛋白质芯片、细胞芯片和组织芯片,它们被广泛地应用于生命科学研究及其实践的各个领域。生物芯片的飞速发展推动了环境污染物快速评价技术的发展,改变了传统的环境流行病学评估模式。本文通过分析生物芯片在基因组学、蛋白组学、细胞学及组织分析中的原理及应用,探讨它们在环境毒理学与环境流行病学研究中存在的问题及研究展望。
Objective Biochips as one of the emerging modern toxicology research techniques to make up for and overcome the traditional shortcomings of toxicology, rapid and high-throughput toxicological exposure information can be processed and analyzed according to the toxicological differences in the analysis of toxicological information screening Role-sensitive target. Biochips include gene chips, protein chips, cell chips and tissue chips, which are widely used in various fields of life science research and its practice. The rapid development of bio-chips has promoted the rapid development of environmental pollutants evaluation technology, changing the traditional environmental epidemiological assessment model. In this paper, by analyzing the principles and applications of biochips in genomics, proteomics, cytology and tissue analysis, we discuss their problems and prospects in the field of environmental toxicology and environmental epidemiology.