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三氟乙酰伯喹(M—8506)经动物试验初步证明,它对食蟹猴疟原虫子孢子感染阳性猴的根治作用优于伯喹,对小鼠的急性毒性明显低于伯喹。为了进一步了解 M—8506对猴疟的根治疗效是否比伯喹好,以判断是否值得更深入研究提供可靠依据,乃以食蟹猴疟原虫子孢子感染的阳性猴作 M—8506与伯喹根治疗效的进一步比较。一、材料与方法食蟹猴疟原虫(Plasmodium cynomolgi)于1967年从越南引进,经过鉴定亦称猴间日疟原虫。斯氏按蚊(Anopheles stephensi)于1973年从英国伦敦 Horton 医院引进,定名为 Hor 株。恒河猴(Macaca rhesus)购自广西,体重2.0～5.5kg,雌雄不拘。12只试验猴中2只猴从未
Trifluoroacetyl primaquine (M-8506) preliminary evidence of animal experiments, it is positive for cercosporidium malaria parasitic positive monkey than primaquine, acute toxicity in mice was significantly lower than that of primaquine. In order to further understand whether the curative effect of M-8506 on monkey malaria is better than that of primaquine, to determine whether it is worthy of further study to provide a reliable basis, positive monkey infected with Plasmodium malariae sporozoites as M-8506 and primaquine Further efficacy comparison. Materials and Methods Plasmodium cynomolgi was introduced from Vietnam in 1967 and identified as Plasmodium vivax. Anopheles stephensi was introduced from Horton Hospital in London, England in 1973 and is named Hor strain. Macaca rhesus was purchased from Guangxi with a body weight of 2.0-5.5 kg and was neither male nor female. Twelve monkeys in 12 monkeys never