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目的本研究拟揭示中国汉族人群Hcy血浆水平与高血压的关系。方法采用循环酶法检测4989例山东日照社区人群血浆Hcy水平,分析Hcy血浆水平与血压及高血压患病的关系。结果 (1)随着Hcy血浆水平升高,高血压患者比例逐渐增加,Hcy血浆水平第二、三、四四分位组的高血压患者比例分别为第一四分位组的1.58倍、2.09倍和2.25倍,P<0.001;(2)高血压患病与Hcy血浆水平升高显著相关,logistic回归校正了年龄、性别、体重指数、吸烟、饮酒等传统危险因素后,与Hcy水平最低四分位相比,第四四分位危险比(95%CI)为1.30(1.03-1.66),P<0.05;进一步校正TC、HDL-C、LDL-C、血糖、尿酸、TG后,其相关性则不再有显著意义。结论 Hcy血浆水平升高与高血压患病显著相关,是高血压患病的标志物,但不是高血压患病的独立危险因素。
Objective This study was designed to reveal the relationship between Hcy plasma level and hypertension in Chinese Han population. Methods Cyclic enzyme was used to detect plasma Hcy levels in 4989 Rizhao communities of Shandong Province. The relationship between Hcy plasma level and the prevalence of hypertension and hypertension was analyzed. Results (1) With the increase of Hcy plasma level, the proportion of hypertensive patients increased gradually. The proportion of Hypertension patients with Hcy plasma levels in the second, third and fourth quartiles were 1.58 times and 2.09 times respectively in the first quartile Fold and 2.25-fold, respectively, P <0.001; (2) The prevalence of hypertension was significantly associated with Hcy plasma levels. Logistic regression adjusted for the lowest risk of Hcy with traditional risk factors such as age, sex, body mass index HDL-C, LDL-C, blood glucose, uric acid and TG were significantly lower than those of the control group (P <0.05). The hazard ratio (95% CI) was 1.30 (1.03-1.66) Then no longer significant. Conclusions Hcy plasma level is significantly associated with the prevalence of hypertension and is a marker of hypertension, but it is not an independent risk factor for hypertension.