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阿克拉霉素B是一种新型蒽环类抗肿瘤抗生素阿克拉霉素A的同系物,对小鼠白血病L-1210、P-388S-180及Lewis肺癌有抑制作用。已有文章对其毒性、在动物血液中浓度的动态变化以及体内代谢及作用机制等进行了研究。为深入研究其作用原理,我们观察了阿克拉霉素B对人早幼粒白血病细胞的分化诱导作用。
Aclacinomycin B is a homolog of aclacinomycin A, a novel anthracycline antitumor antibiotic, that inhibits murine leukemia L-1210, P-388S-180 and Lewis lung carcinoma. There are articles on its toxicity, dynamic changes in animal blood concentration and metabolism in vivo and mechanism of action were studied. In order to further study its mechanism of action, we observed the effect of aclacinomycin B on differentiation of human promyelocytic leukemia cells.