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目的 探讨同时应用支气管动脉灌注化疗和外放射治疗两种疗法治疗中晚期肺癌的疗效。方法 采用Seldinger’技术 ,经支气管动脉灌注化疗药物 :顺铂 80mg ,阿霉素 5 0mg ,丝裂霉素 10mg或 5 -氟脲嘧啶 10 0 0mg。每 3～ 4周灌注一次 ,3～ 4次为一疗程。放疗于灌注后 10～ 15天进行。放射源为60 Co ,所有病例均行对穿照射。剂量DT2 0 0cGy/次 ,5次 /周 ,总量DT5 0 0 0～ 60 0 0cGy/2 5～ 3 0次 ,共 5～ 6周。结果 CR 8例 ( 2 2 2 % ) ,PR 2 3例 ( 63 6% ) ,S 3例 ( 8 6% ) ,P 2例 ( 5 65 % )。总有效率CR +PR为 85 6% ,2年生存率2 7 8%。结论 支气管动脉灌注加外照射治疗肺癌有协同作用 ,是目前治疗中晚期肺癌的一种安全、有效的方法。
Objective To investigate the efficacy of simultaneous bronchial arterial infusion chemotherapy and external radiation therapy for the treatment of advanced lung cancer. Methods Seldinger’ technique was used to infuse chemotherapy drugs via bronchial arterial infusion: cisplatin 80 mg, doxorubicin 50 mg, mitomycin 10 mg or 5-fluorouracil 100 mg. Perfusion every 3 to 4 weeks, 3 to 4 times for a course of treatment. Radiotherapy was performed 10 to 15 days after perfusion. The radiation source was 60 Co and all cases were exposed to radiation. Dose DT2 0 0cGy / times, 5 times / week, the total amount DT500 ~ 60 0 0cGy/2 5 ~ 3 times, a total of 5 to 6 weeks. Results Eight patients had CR (22%), PR23 patients (636%), S3 patients (86%), and P2 patients (565%). The total effective rate of CR + PR was 85.6%, and the 2-year survival rate was 27.78%. Conclusion Bronchial arterial infusion plus external irradiation has a synergistic effect on lung cancer, which is a safe and effective method for the treatment of advanced lung cancer.